BREAST CANCER – HER 2 +

Setting

Trial

Status

 Network

1st Line Metastatic

GSK EGF 108919 – Taxane + Herceptin vs. Taxane + Lapatinib

OPEN

Suburban

ADJUVANT

CIRG/TRIO (011BETH)–TCH/AVASTIN vs TCH

OPEN

TORI

HER2-

ADJUVANT

TITAN- AC/Taxol vs AC/Ixempra for triple negative breast cancer

OPEN

Suburban

ADJUVANT

ROCHE – TC/ TAC/TOE (Avastin arm)

OPEN

TORI

1st, 2nd, 3rd Line metastatic breast cancer – triple negative

BiPar EAP-Gemzar/Carbo + parp inhibitor (BSI-201)

OPEN

TORI

1st Line metastatic

TRIO 018 – Letrozole + or – PD 0332991 (oral CDK inhibitor) for ER +, HER2 – metastatic breast cancer in post menopausal women

OPEN

TORI

Refractory breast

Novartis TK12202 – Open label TK1258 in FGFR amplified and non amplified metastatic HER2 – breast cancer

OPEN

TORI

1st Line Metastatic Registry

VIRGO – Observational study of treatment for 1st line or locally recurrent

OPEN

Suburban

1st Line Metastatic – non treatment

Best Rx – Metastatic breast block collection

OPEN

TORI

HER-2 + OR -

Neoadjuvant

O’Regan trial: Taxotere + Xeloda sequentially or concomitantly

OPEN

Suburban

Metastatic

Zometa q 4 wk vs. q 12 wk vs. placebo after treatment with Zometa for at least 9 – 12 months – NO UPPER LIMIT ON DOSES

OPEN

Suburban

 

COLON/GI CANCER

2nd Line metastatic

Amgen 20060141.FOLFIRI + Avastin vs. FOLFIRI + Panitumumab

OPEN

TORI

Refractory colon

Perifosine 343 – Xeloda = or – Perifosine (oral AKT inhibitor)

OPEN

Suburban

2nd or 3rd Line Esophageal/Gastric

TORI GI-06 – Rad 001 (mTOR inhibitor)

OPEN

TORI

Adjuvant pancreatic

TORI PA-01 Gemzar + Dasatinib vs. Gemzar alone

OPEN

TORI

 

LUNG/NSCLC

1st Line metastatic adenocarcinoma or squamous

Acorn AC01L08 – Erbitux + platinum based chemo

OPEN

Suburban

1st Line metastatic non-squamous lung cancer

JMHD – Taxol/Carbo/Bev vs. Alimta/Carbo/ Bev

OPEN

Suburban

1st Line metastatic squamous NSCLC

LUN – 201 Carbo/Gemzar + or – BSI-201 (parp inhibitor)

OPEN

Suburban

2nd Line

BI 1199.14 – Alimta + BIBF1120 (small molecule TKI)

OPEN

Suburban

2nd Line

CASA – Taxotere + or – ASA404 (T-VDA)

OPEN

TORI

2nd, 3rd Line

LUN 200 – Erlotonib + Pazopanib/Placebo

OPEN

Suburban

 

OTHER STUDIES

GIST

Registry – Gastrointestinal Stromal Tumors registry

OPEN

Suburban

Prostate

BMS CA180227 – Taxotere + or – Dasatinib for castration resistant prostate cancer

OPEN

Suburban

Prostate – 2nd or 3rd line

BMS CA 184-043 – Ipilimumab immunotherapy/ placebo

OPEN

Suburban